Article
Differential parental transmission of markers in RUNX2 among cleft case-parent trios from four populations.
Genetic epidemiology - 1 Sept 2008
Sull Jae Woong, Liang Kung-Yee, Hetmanski Jacqueline B, Fallin Margaret Daniele, Ingersoll Roxann G, Park Jiwan, Wu-Chou Yah-Huei, Chen Philip K, Chong Samuel S, Cheah Felicia, Yeow Vincent, Park Beyoung Yun, Jee Sun Ha, Jabs Ethylin Wang, Redett Richard, Jung Euiju, Ruczinski Ingo, Scott Alan F, Beaty Terri H
Abstract excerpt
Isolated cleft lip with or without cleft palate (CL/P) is among the most common human birth defects, with a prevalence around 1 in 700 live births. The Runt-related transcription factor 2 (RUNX2) gene has been suggested as a candidate gene for CL/P based largely on mouse models; however, no human studies have focused on RUNX2 as a risk factor for CL/P. This study examines the association between markers in RUNX2...
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