Article
Evidence of gene-environment interaction for the IRF6 gene and maternal multivitamin supplementation in controlling the risk of cleft lip with/without cleft palate.
Human genetics - 1 Oct 2010
Wu Tao, Liang Kung Yee, Hetmanski Jacqueline B, Ruczinski Ingo, Fallin Margaret Daniele, Ingersoll Roxann G, Wang Hong, Huang Shangzhi, Ye Xiaoqian, Wu-Chou Yah-Huei, Chen Philip K, Jabs Ethylin W, Shi Bing, Redett Richard, Scott Alan F, Beaty Terri H
Abstract excerpt
Although multiple genes have been identified as genetic risk factors for isolated, non-syndromic cleft lip with/without cleft palate (CL/P), a complex and heterogeneous birth defect, interferon regulatory factor 6 gene (IRF6) is one of the best documented genetic risk factors. In this study, we tested for association between markers in IRF6 and CL/P in 326 Chinese case-parent trios, considering gene-environment...
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