Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate.

doi:10.1002/gepi.20595

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Article

Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate.

Genetic epidemiology - 1 Sept 2011

Beaty Terri H, Ruczinski Ingo, Murray Jeffrey C, Marazita Mary L, Munger Ronald G, Hetmanski Jacqueline B, Murray Tanda, Redett Richard J, Fallin M Daniele, Liang Kung Yee, Wu Tao, Patel Poorav J, Jin Sheng-Chih, Zhang Tian Xiao, Schwender Holger, Wu-Chou Yah Huei, Chen Philip K, Chong Samuel S, Cheah Felicia, Yeow Vincent, Ye Xiaoqian, Wang Hong, Huang Shangzhi, Jabs Ethylin W, Shi Bing, Wilcox Allen J, Lie Rolv T, Jee Sun Ha, Christensen Kaare, Doheny Kimberley F, Pugh Elizabeth W, Ling Hua, Scott Alan F

Abstract excerpt

Nonsyndromic cleft palate (CP) is a common birth defect with a complex and heterogeneous etiology involving both genetic and environmental risk factors. We conducted a genome-wide association study (GWAS) using 550 case-parent trios, ascertained through a CP case collected in an international consortium. Family-based association tests of single nucleotide polymorphisms (SNP) and three common maternal exposures...

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Identifiers

PMID: 21618603
DOI: 10.1002/gepi.20595
PMCID: PMC3180858

Genes

BAALC
MLLT3
SMC2
TBK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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