Evidence of gene-environment interaction for two genes on chromosome 4 and environmental tobacco smoke in controlling the risk of nonsyndromic cleft palate.

doi:10.1371/journal.pone.0088088

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Article

Evidence of gene-environment interaction for two genes on chromosome 4 and environmental tobacco smoke in controlling the risk of nonsyndromic cleft palate.

PloS one - 1 Jan 2014

Wu Tao, Schwender Holger, Ruczinski Ingo, Murray Jeffrey C, Marazita Mary L, Munger Ronald G, Hetmanski Jacqueline B, Parker Margaret M, Wang Ping, Murray Tanda, Taub Margaret, Li Shuai, Redett Richard J, Fallin M Daniele, Liang Kung Yee, Wu-Chou Yah Huei, Chong Samuel S, Yeow Vincent, Ye Xiaoqian, Wang Hong, Huang Shangzhi, Jabs Ethylin W, Shi Bing, Wilcox Allen J, Jee Sun Ha, Scott Alan F, Beaty Terri H

Abstract excerpt

Nonsyndromic cleft palate (CP) is one of the most common human birth defects and both genetic and environmental risk factors contribute to its etiology. We conducted a genome-wide association study (GWAS) using 550 CP case-parent trios ascertained in an international consortium. Stratified analysis among trios with different ancestries was performed to test for GxE interactions with common maternal exposures...

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PMID: 24516586
DOI: 10.1371/journal.pone.0088088
PMCID: PMC3916361

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