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Article

Evidence that TGFA influences risk to cleft lip with/without cleft palate through unconventional genetic mechanisms.

Human genetics - 1 Sept 2009

Sull Jae Woong, Liang Kung-Yee, Hetmanski Jacqueline B, Wu Tao, Fallin Margaret Daniele, Ingersoll Roxann G, Park Ji Wan, Wu-Chou Yah-Huei, Chen Philip K, Chong Samuel S, Cheah Felicia, Yeow Vincent, Park Beyoung Yun, Jee Sun Ha, Jabs Ethylin Wang, Redett Richard, Scott Alan F, Beaty Terri H

Abstract excerpt

This study examined the association between markers in transforming growth factor alpha (TGFA) and isolated, non-syndromic cleft lip with/without palate (CL/P) using a case-parent trio design, considering parent-of-origin effects. We also tested for gene-environmental interaction with common mate...

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Source

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Identifiers

PMID: 19444471
DOI: 10.1007/s00439-009-0680-3
PMCID: PMC2901599

Genes

TGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19444471-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Evidence that TGFA influences risk to cleft lip with/without cleft palate through unconventional genetic mechanisms.PMID 19444471Read ↗

Genetic effect of transforming growth factor alpha gene variants on the risk of nonsyndromic cleft lip with or without palate in korean populations.Semantic proximity Read ↗

TGFA and IRF6 contribute to the risk of nonsyndromic cleft lip with or without cleft palate in northeast China.Semantic proximity Read ↗

Transforming Growth Factor Alpha Taq I Polymorphisms and Nonsyndromic Cleft Lip and/or Palate Risk: A Meta-Analysis.Semantic proximity Read ↗

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Differential parental transmission of markers in RUNX2 among cleft case-parent trios from four populations.Semantic proximity Read ↗

[Gene-gene/gene-environment interaction of transforming growth factor-β signaling pathway and the risk of non-syndromic oral clefts].Semantic proximity Read ↗

Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate.Semantic proximity Read ↗

TGFB3 displays parent-of-origin effects among central Europeans with nonsyndromic cleft lip and palate.Semantic proximity Read ↗

[Association study between candidate genes on transforming growth factor-β signaling pathway and the risk of non-syndromic cleft lip with or without cleft palate in Chinese populations].Semantic proximity Read ↗

Association between polymorphism of TGFA Taq I and cleft lip and/or palate: a meta-analysis.Semantic proximity Read ↗

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