Article
Gene-gene interaction of single nucleotide polymorphisms in 16p13.3 may contribute to the risk of non-syndromic cleft lip with or without cleft palate in Chinese case-parent trios.
American journal of medical genetics. Part A - 1 Jun 2017
Liu Dongjing, Wang Hong, Schwender Holger, Marazita Mary L, Wang Zhuqing, Yuan Yuan, Wang Ping, Liang Kung Yee, Wu-Chou Yah Huei, Wang Mengying, Shi Bing, Zhu Hongping, Wu Tao, Beaty Terri H
Abstract excerpt
Non-syndromic cleft lip with or without cleft palate (NSCL/P) is a common birth defect with a complex and heterogeneous etiology. A recent genome-wide association study (GWAS) among Chinese populations has identified a new region at 16p13.3 as being associated with NSCL/P, which requires further replication. Here, we attempted to replicate and further clarify the genetic association between this region and...
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