Article
Joint testing of genotypic and gene-environment interaction identified novel association for BMP4 with non-syndromic CL/P in an Asian population using data from an International Cleft Consortium.
PloS one - 1 Jan 2014
Chen Qianqian, Wang Hong, Schwender Holger, Zhang Tianxiao, Hetmanski Jacqueline B, Chou Yah-Huei Wu, Ye Xiaoqian, Yeow Vincent, Chong Samuel S, Zhang Bo, Jabs Ethylin Wang, Parker Margaret M, Scott Alan F, Beaty Terri H
Abstract excerpt
BACKGROUND: Non-syndromic cleft lip with or without cleft palate (NSCL/P) is a common disorder with complex etiology. The Bone Morphogenetic Protein 4 gene (BMP4) has been considered a prime candidate gene with evidence accumulated from animal experimental studies, human linkage studies, as well as candidate gene association studies. The aim of the current study is to test for linkage and association between BMP4...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.