Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PRAS40 Is a Functionally Critical Target for EWS Repression in Ewing Sarcoma

13 Jan 2012

Abstract excerpt

Ewing sarcoma family tumors (ESFT) are highly aggressive and highly metastatic tumors caused by a chromosomal fusion between the Ewing sarcoma protein (EWS) with the transcription factor FLI-1. However, expression of the EWS/FLI-1 chimeric oncogene by itself is insufficient for carcinogenesis, suggesting that additional events are required. Here, we report the identification of the Akt substrate PRAS40 as an EWS...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lymphoma Diagnosis and Treatment
Share to RNA Research and Splicing
Share to Sarcoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22241085
DOI: 10.1158/0008-5472.can-11-2254

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PRAS40 Is a Functionally Critical Target for EWS Repression in Ewing SarcomaPMID 22241085Read ↗

EWS-FLI1 positively regulates autophagy by increasing ATG4B expression in Ewing sarcoma cellsSemantic proximity Read ↗

The Controversial Role of Autophagy in Ewing Sarcoma Pathogenesis—Current Treatment OptionsSemantic proximity Read ↗

Pharmacological targeting of P300/CBP reveals EWS::FLI1-mediated senescence evasion in Ewing sarcomaSemantic proximity Read ↗

STAT3 is activated in a subset of the Ewing sarcoma family of tumoursSemantic proximity Read ↗

Targeting of EWS/FLI-1 by RNA interference attenuates the tumor phenotype of Ewing's sarcoma cells in vitro.Semantic proximity Read ↗

The possible role of EWS-Fli1 in evasion of senescence in Ewing family tumors.Semantic proximity Read ↗

EWS/FLI1 suppresses retinoblastoma protein function and senescence in Ewing's sarcoma cells.Semantic proximity Read ↗

The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcomaSemantic proximity Read ↗

Suppression of the Ewing's sarcoma phenotype by FLI1/ERF repressor hybrids.Semantic proximity Read ↗

Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines.Semantic proximity Read ↗

Cooperative DNA binding with AP-1 proteins is required for transformation by EWS-Ets fusion proteins.Semantic proximity Read ↗

Tumor suppressive microRNA-138 inhibits metastatic potential via the targeting of focal adhesion kinase in Ewing's sarcoma cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.