Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcoma

7 Nov 2015

Abstract excerpt

Ewing sarcoma is a cancer of bone and soft tissue in children that is characterized by a chromosomal translocation involving EWS and an Ets family transcription factor, most commonly FLI-1. The EWS-FLI-1 fusion oncogene is widely believed to play a central role in Ewing sarcoma. The EWS-FLI-1 gene product regulates the expression of a number of genes important for cancer progression, can transform mouse cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lymphoma Diagnosis and Treatment
Share to RNA Research and Splicing
Share to Sarcoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26807198
DOI: 10.18632/genesandcancer.86

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcomaPMID 26807198Read ↗

EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing SarcomaSemantic proximity Read ↗

Ewing tumor biology: perspectives for innovative treatment approaches.Semantic proximity Read ↗

The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts.Semantic proximity Read ↗

Transformation induced by Ewing's sarcoma associated EWS/FLI-1 is suppressed by KRAB/FLI-1.Semantic proximity Read ↗

Identification of target genes in their native cellular context: an analysis of EWS/FLI in Ewing's sarcoma.Semantic proximity Read ↗

A Molecular Function Map of Ewing's SarcomaSemantic proximity Read ↗

EWS-FLI1 and Ewing's sarcoma: recent molecular data and new insights.Semantic proximity Read ↗

EWS/FLI1 Characterization, Activation, Repression, Target Genes and Therapeutic Opportunities in Ewing SarcomaSemantic proximity Read ↗

Ewing sarcoma fusion oncogene: At the crossroads of transcription and DNA damage responseSemantic proximity Read ↗

Downstream EWS/FLI1 - upstream Ewing's sarcomaSemantic proximity Read ↗

A zebrafish transgenic model of Ewing’s sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesisSemantic proximity Read ↗

Interference with the constitutive activation of ERK1 and ERK2 impairs EWS/FLI-1-dependent transformation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.