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Article

Targeting of EWS/FLI-1 by RNA interference attenuates the tumor phenotype of Ewing's sarcoma cells in vitro.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Jul 2004

Chansky Howard A, Barahmand-Pour Fariba, Mei Qi, Kahn-Farooqi Waqqar, Zielinska-Kwiatkowska Anna, Blackburn Michael, Chansky Kari, Conrad Ernest U, Bruckner James D, Greenlee Theodore K, Yang Liu

Abstract excerpt

The defining cytogenetic abnormality of Ewing's sarcoma is the presence of a balanced t(11;22) translocation expressing the EWS/FLI-1 chimeric fusion protein. The effect of EWS/FLI-1 appears to be dominant negative since over-expression of EWS does not overcome the sarcoma phenotype. Previous studies have shown that EWS/FLI-1 as well as related sarcoma fusion proteins are necessary and sufficient to induce...

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Share to Gene Silencing
Share to Genes, Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogene Proteins, Fusion

Share to Proto-Oncogene Protein c-fli-1

Share to Receptors, CXCR4

Share to RNA-Binding Protein EWS

Share to RNA, Small Interfering

Share to Sarcoma, Ewing

Source

Identifiers

PMID: 15183454
DOI: 10.1016/j.orthres.2003.12.008

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Targeting of EWS/FLI-1 by RNA interference attenuates the tumor phenotype of Ewing's sarcoma cells in vitro.PMID 15183454Read ↗

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Transformation induced by Ewing's sarcoma associated EWS/FLI-1 is suppressed by KRAB/FLI-1.Semantic proximity Read ↗

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The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcomaSemantic proximity Read ↗

CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1–Dependent IGF-1 SignalingSemantic proximity Read ↗

The EWS/FLI Oncogene Drives Changes in Cellular Morphology, Adhesion, and Migration in Ewing SarcomaSemantic proximity Read ↗

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Ewing's Sarcoma Oncoprotein EWS–FLI1: The Perfect Target Without a Therapeutic AgentSemantic proximity Read ↗

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