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Article

EWS-FLI1 positively regulates autophagy by increasing ATG4B expression in Ewing sarcoma cells

29 Aug 2017

Abstract excerpt

Ewing sarcoma (ES) is the most common malignant bone tumor in children and young adults. It is characterized by chromosomal translocations fusing the EWS gene with an ETS oncogene, most frequently FLI1. In the present study, the authors aimed to investigate the function of EWS-FLI1 in autophagy in ES cells, and identified that EWS-FLI1 positively regulates autophagy in ES cells. ATG4B expression was observed...

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Identifiers

PMID: 28902354
DOI: 10.3892/ijmm.2017.3112

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