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Article

Cooperative DNA binding with AP-1 proteins is required for transformation by EWS-Ets fusion proteins.

Molecular and cellular biology - 1 Apr 2006

Kim Sungeun, Denny Christopher T, Wisdom Ron

Abstract excerpt

A key molecular event in the genesis of Ewing's sarcoma is the consistent presence of chromosomal translocations that result in the formation of proteins in which the amino terminus of EWS is fused to the carboxyl terminus, including the DNA binding domain, of one of five different Ets family proteins. These fusion proteins function as deregulated transcription factors, resulting in aberrant control of gene...

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Topics

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Share to NIH 3T3 Cells
Share to Proto-Oncogene Protein c-ets-1
Share to Proto-Oncogene Protein c-fli-1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins c-fos

Share to Proto-Oncogene Proteins c-jun

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Share to RNA-Binding Protein EWS

Share to Transcription Factor AP-1

Source

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Identifiers

PMID: 16537893
DOI: 10.1128/MCB.26.7.2467-2478.2006
PMCID: PMC1430316

Genes

ERG
ETV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cooperative DNA binding with AP-1 proteins is required for transformation by EWS-Ets fusion proteins.PMID 16537893Read ↗

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