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Article

EWS/FLI1 suppresses retinoblastoma protein function and senescence in Ewing's sarcoma cells.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Jun 2008

Hu Hsien-Ming, Zielinska-Kwiatkowska Anna, Munro Karen, Wilcox Jason, Wu Daniel Y, Yang Liu, Chansky Howard A

Abstract excerpt

Ewing's Family Tumors (EFTs) most commonly harbor a specific t(11;22) translocation that generates the EWS/FLI1 fusion protein responsible for malignant transformation. Many potential downstream targets of EWS/FLI1 have been identified but a detailed mechanism by which the fusion protein brings a...

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Source

Identifiers

PMID: 18271016
DOI: 10.1002/jor.20597

Genes

FLI1
CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18271016-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EWS/FLI1 suppresses retinoblastoma protein function and senescence in Ewing's sarcoma cells.PMID 18271016Read ↗

The possible role of EWS-Fli1 in evasion of senescence in Ewing family tumors.Semantic proximity Read ↗

CREG1 enhances p16 INK4a -induced cellular senescenceSemantic proximity Read ↗

Pharmacological targeting of P300/CBP reveals EWS::FLI1-mediated senescence evasion in Ewing sarcomaSemantic proximity Read ↗

Transformation induced by Ewing's sarcoma associated EWS/FLI-1 is suppressed by KRAB/FLI-1.Semantic proximity Read ↗

Downregulation and forced expression of EWS-Fli1 fusion gene results in changes in the expression of G1regulatory genesSemantic proximity Read ↗

Loss of p16 pathways stabilizes EWS/FLI1 expression and complements EWS/FLI1 mediated transformation.Semantic proximity Read ↗

NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma.Semantic proximity Read ↗

Targeting the EWSR1-FLI1 Oncogene-Induced Protein Kinase PKC-β Abolishes Ewing Sarcoma GrowthSemantic proximity Read ↗

BCL11B is up-regulated by EWS/FLI and contributes to the transformed phenotype in Ewing sarcoma.Semantic proximity Read ↗

Ewing's Sarcoma Oncoprotein EWS–FLI1: The Perfect Target Without a Therapeutic AgentSemantic proximity Read ↗

Regulation of a Senescence Checkpoint Response by the E2F1 Transcription Factor and p14 <sup>ARF</sup> Tumor SuppressorSemantic proximity Read ↗

Proteasomal Degradation of the EWS-FLI1 Fusion Protein Is Regulated by a Single Lysine Residue.Semantic proximity Read ↗

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