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Article

Suppression of the Ewing's sarcoma phenotype by FLI1/ERF repressor hybrids.

Cancer gene therapy - 1 Aug 2000

Athanasiou M, LeGallic L, Watson D K, Blair D G, Mavrothalassitis G

Abstract excerpt

Fusion of the 5' half of the Ewing's sarcoma (ES) gene EWS with the DNA-binding domain of several transcription factors has been detected in many human tumors. The t(11;22)(q24;q12) chromosomal translocation is specifically linked to ES and primitive neuroectodermal tumors and results, in the majority of cases, in the fusion of the amino terminus of the EWS gene to the carboxyl-terminal DNA-binding domain of the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10975680
DOI: 10.1038/sj.cgt.7700220

Genes

FLI1
ERF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Suppression of the Ewing's sarcoma phenotype by FLI1/ERF repressor hybrids.PMID 10975680Read ↗

DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma.Semantic proximity Read ↗

Downstream EWS/FLI1 - upstream Ewing's sarcomaSemantic proximity Read ↗

Epigenetic and Transcriptional Signaling in Ewing Sarcoma—Disease Etiology and Therapeutic OpportunitiesSemantic proximity Read ↗

Transformation induced by Ewing's sarcoma associated EWS/FLI-1 is suppressed by KRAB/FLI-1.Semantic proximity Read ↗

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.Semantic proximity Read ↗

NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma.Semantic proximity Read ↗

IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.Semantic proximity Read ↗

Identification of target genes in their native cellular context: an analysis of EWS/FLI in Ewing's sarcoma.Semantic proximity Read ↗

Ewing's Sarcoma Oncoprotein EWS–FLI1: The Perfect Target Without a Therapeutic AgentSemantic proximity Read ↗

The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcomaSemantic proximity Read ↗

Targeting of EWS/FLI-1 by RNA interference attenuates the tumor phenotype of Ewing's sarcoma cells in vitro.Semantic proximity Read ↗

Downregulation and forced expression of EWS-Fli1 fusion gene results in changes in the expression of G1regulatory genesSemantic proximity Read ↗

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