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Article

The possible role of EWS-Fli1 in evasion of senescence in Ewing family tumors.

Cancer research - 15 Jan 2006

Matsunobu Tomoya, Tanaka Kazuhiro, Nakamura Tomoyuki, Nakatani Fumihiko, Sakimura Riku, Hanada Masuo, Li Xu, Okada Takamitsu, Oda Yoshinao, Tsuneyoshi Masazumi, Iwamoto Yukihide

Abstract excerpt

The chromosomal translocation t(11;22) yields the EWS-Fli1 fusion gene and is associated with oncogenesis of Ewing family tumors (EFT). In this study, using the RNA interference method, we show that EWS-Fli1-targeting small interfering RNAs (siRNA) depleted EWS-Fli1 protein and caused growth inhibition in EFT cells with the accumulation of p27 protein and the down-regulation of Skp2 protein in dose-dependent,...

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Share to Cellular Senescence
Share to Cyclin-Dependent Kinase Inhibitor p27

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogene Proteins, Fusion

Share to Proto-Oncogene Protein c-fli-1

Share to RNA-Binding Protein EWS

Share to RNA, Small Interfering

Share to S-Phase Kinase-Associated Proteins

Share to Sarcoma, Ewing

Source

Identifiers

PMID: 16424012
DOI: 10.1158/0008-5472.CAN-05-1972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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