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Article

Association study of CYP17 and HSD11B1 in polycystic ovary syndrome utilizing comprehensive gene coverage.

Molecular human reproduction - 1 Jun 2012

Chua Angela K, Azziz Ricardo, Goodarzi Mark O

Abstract excerpt

Cytochrome P450-C17 enzyme (CYP17) is an important component of the androgen synthesis pathway, a pathway that is dysfunctional in polycystic ovary syndrome (PCOS). Variation in 11-beta hydroxysteroid dehydrogenase (HSD11B1) is associated with cortisone reductase deficiency, a condition with a phenotype similar to PCOS. Both CYP17 and HSD11B1 genes have been previously studied for their possible relationship with...

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PMID: 22238371
DOI: 10.1093/molehr/gas002
PMCID: PMC3358039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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