Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variants of the HSD11B1 gene promoter may be protective against polycystic ovary syndrome.

Molecular biology reports - 1 Sept 2014

Grolmusz Vince Kornél, Acs Orsolya Dóra, Feldman-Kovács Karolina, Szappanos Ágnes, Stenczer Balázs, Fekete Tibor, Szendei György, Reismann Péter, Rácz Károly, Patócs Attila

Abstract excerpt

The HSD11B1 gene encodes the type 1 isoform of the 11-β-hydroxysteroid dehydrogenase that is responsible for the regeneration of glucocorticoids from hormonally-inactive metabolites into active forms in a tissue-specific manner. Altered activity of the enzyme, and certain genetic variants of the HSD11B1 gene, has been associated with various metabolic morbidities. In this study, our aim was to systematically test...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Association Studies
Share to Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polycystic Ovary Syndrome

Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

Share to Young Adult

Source

Identifiers

PMID: 24969481
DOI: 10.1007/s11033-014-3473-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variants of the HSD11B1 gene promoter may be protective against polycystic ovary syndrome.PMID 24969481Read ↗

A combination of polymorphisms in HSD11B1 associates with in vivo 11β-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndromeSemantic proximity Read ↗

The rs4844880 polymorphism in the promoter region of the HSD11B1 gene associates with bone mineral density in healthy and postmenopausal osteoporotic women.Semantic proximity Read ↗

Glucocorticoid synthesis-related genes: HSD11B1 and HSD11B2 in hypertensive disorders in pregnancy.Semantic proximity Read ↗

Functional effects of polymorphisms in the human gene encoding 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1): a sequence variant at the translation start of 11 beta-HSD1 alters enzyme levels.Semantic proximity Read ↗

Association of the 17-hydroxysteroid dehydrogenase type 5 gene polymorphism (-71A/G HSD17B5 SNP) with hyperandrogenemia in polycystic ovary syndrome (PCOS).Semantic proximity Read ↗

Regulatory effect of common promoter polymorphisms on the expression of the 11beta-hydroxysteroid dehydrogenase type 1 gene.Semantic proximity Read ↗

Association between 11beta-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in Bosnian population.Semantic proximity Read ↗

Polymorphism in HSD17B6 is associated with key features of polycystic ovary syndrome.Semantic proximity Read ↗

Impact of Missense Variants on the Structure and Function of Polycystic Ovary Syndrome-Associated HSD17B1 Gene.Semantic proximity Read ↗

Association Analysis between the Polymorphisms of HSD11B1 and H6PD and Risk of Polycystic Ovary Syndrome in Chinese Population.Semantic proximity Read ↗

Polymorphic variants of the HSD11B1 gene may be involved in adverse metabolic effects of glucocorticoid replacement therapy in Addison's disease.Semantic proximity Read ↗

Association of HSD11B1 gene polymorphisms with type 2 diabetes and metabolic syndrome in South Indian population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.