Genetic variation in the HSD17B1 gene and risk of prostate cancer.

doi:10.1371/journal.pgen.0010068

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Article

Genetic variation in the HSD17B1 gene and risk of prostate cancer.

PLoS genetics - 1 Nov 2005

Kraft Peter, Pharoah Paul, Chanock Stephen J, Albanes Demetrius, Kolonel Laurence N, Hayes Richard B, Altshuler David, Andriole Gerald, Berg Christine, Boeing Heiner, Burtt Noel P, Bueno-de-Mesquita Bas, Calle Eugenia E, Cann Howard, Canzian Federico, Chen Yen-Ching, Crawford David E, Dunning Alison M, Feigelson Heather S, Freedman Matthew L, Gaziano John M, Giovannucci Ed, Gonzalez Carlos Alberto, Haiman Christopher A, Hallmans Goran, Henderson Brian E, Hirschhorn Joel N, Hunter David J, Kaaks Rudolf, Key Timothy, Le Marchand Loic, Ma Jing, Overvad Kim, Palli Domenico, Pike Malcolm C, Riboli Elio, Rodriguez Carmen, Setiawan Wendy V, Stampfer Meir J, Stram Daniel O, Thomas Gilles, Thun Michael J, Travis Ruth, Trichopoulou Antonia, Virtamo Jarmo, Wacholder Sholom

Abstract excerpt

Steroid hormones are believed to play an important role in prostate carcinogenesis, but epidemiological evidence linking prostate cancer and steroid hormone genes has been inconclusive, in part due to small sample sizes or incomplete characterization of genetic variation at the locus of interest. Here we report on the results of a comprehensive study of the association between HSD17B1 and prostate cancer by the...

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PMID: 16311626
DOI: 10.1371/journal.pgen.0010068
PMCID: PMC1287955

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