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Article

Identification of a functional polymorphism of the human type 5 17beta-hydroxysteroid dehydrogenase gene associated with polycystic ovary syndrome.

The Journal of clinical endocrinology and metabolism - 1 Jan 2006

Qin Kenan, Ehrmann David A, Cox Nancy, Refetoff Samuel, Rosenfield Robert L

Abstract excerpt

CONTEXT: Polycystic ovary syndrome (PCOS) is characterized by chronic hyperandrogenic anovulation and is associated with insulin resistance. Its pathogenesis is believed to be multifactorial, and abnormal gene regulation could be one contributing factor. Type 5 17beta-hydroxysteroid dehydrogenase (17beta-HSD5) appears to be the major testosterone-forming 17beta-HSD isoenzyme in females. OBJECTIVE: Our objective...

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Identifiers

PMID: 16263811
DOI: 10.1210/jc.2005-2012
PMCID: PMC1522092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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