Independent confirmation of association between metabolic phenotypes of polycystic ovary syndrome and variation in the type 6 17beta-hydroxysteroid dehydrogenase gene.

doi:10.1210/jc.2009-0931

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Article

Independent confirmation of association between metabolic phenotypes of polycystic ovary syndrome and variation in the type 6 17beta-hydroxysteroid dehydrogenase gene.

The Journal of clinical endocrinology and metabolism - 1 Dec 2009

Jones Michelle R, Mathur Ruchi, Cui Jinrui, Guo Xiuqing, Azziz Ricardo, Goodarzi Mark O

Abstract excerpt

CONTEXT: Few candidate genes for polycystic ovary syndrome (PCOS) are widely agreed upon largely due to lack of replication. Type 6 17beta-hydroxysteroid dehydrogenase (HSD17B6) gene expression is increased in PCOS ovarian theca. Previous genetic study of HSD17B6 reported significant association of rs898611 with PCOS risk and metabolic phenotypes. OBJECTIVE: Our objective was to replicate association between...

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PMID: 19837928
DOI: 10.1210/jc.2009-0931
PMCID: PMC2795666

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