Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pre-existing isoniazid resistance, but not the genotype of Mycobacterium tuberculosis drives rifampicin resistance codon preference in vitro.

PloS one - 1 Jan 2012

Bergval Indra, Kwok Brian, Schuitema Anja, Kremer Kristin, van Soolingen Dick, Klatser Paul, Anthony Richard

Abstract excerpt

Both the probability of a mutation occurring and the ability of the mutant to persist will influence the distribution of mutants that arise in a population. We studied the interaction of these factors for the in vitro selection of rifampicin (RIF)-resistant mutants of Mycobacterium tuberculosis. We characterised two series of spontaneous RIF-resistant in vitro mutants from isoniazid (INH)-sensitive and -resistant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Codon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Genotype

Share to Isoniazid

Share to Mutation Rate

Share to Mycobacterium tuberculosis

Share to Rifampin

Source

Open in PubMed Open full text

Identifiers

PMID: 22235262
DOI: 10.1371/journal.pone.0029108
PMCID: PMC3250395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pre-existing isoniazid resistance, but not the genotype of Mycobacterium tuberculosis drives rifampicin resistance codon preference in vitro.PMID 22235262Read ↗

Resistant mutants of Mycobacterium tuberculosis selected in vitro do not reflect the in vivo mechanism of isoniazid resistance.Semantic proximity Read ↗

Resistance levels and rpoB gene mutations among in vitro-selected rifampin-resistant Mycobacterium tuberculosis mutants.Semantic proximity Read ↗

Acquisition of rifabutin resistance by a rifampicin resistant mutant of Mycobacterium tuberculosis involves an unusual spectrum of mutations and elevated frequency.Semantic proximity Read ↗

The Spectrum of Spontaneous Rifampin Resistance Mutations in the Bacillus subtilis rpoB Gene Depends on the Growth Environment.Semantic proximity Read ↗

Physiological cost of rifampin resistance induced in vitro in Mycobacterium tuberculosis.Semantic proximity Read ↗

Bacterial population kinetics in heteroresistant Mycobacterium tuberculosis harbouring rare resistance-conferring mutations in gyrA and rpoB imply an epistatic interaction of mutations in a pre-XDR-TB patient.Semantic proximity Read ↗

Characterization of Spontaneous, In Vitro-Selected, Rifampin-Resistant Mutants of <i>Mycobacterium tuberculosis</i> Strain H37RvSemantic proximity Read ↗

HIV coinfection is associated with low fitness <i>rpoB</i> variants in rifampicin-resistant <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Effect of rpoB mutations conferring rifampin resistance on fitness of Mycobacterium tuberculosis.Semantic proximity Read ↗

Mutant prevention concentration of isoniazid, rifampicin and rifabutin against Mycobacterium tuberculosis.Semantic proximity Read ↗

Disequilibria in the distribution of rpoB alleles in rifampicin-resistant M. tuberculosis isolates from Germany and Sierra Leone.Semantic proximity Read ↗

The impact of drug resistance on <i>Mycobacterium tuberculosis</i> physiology: what can we learn from rifampicin?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.