Characterization of Spontaneous, In Vitro-Selected, Rifampin-Resistant Mutants of <i>Mycobacterium tuberculosis</i> Strain H37Rv

Abstract excerpt

Resistance to rifampin in Mycobacterium tuberculosis results from mutations in the gene coding for the beta subunit of RNA polymerase (rpoB). At least 95% of rifampin-resistant isolates have mutations in rpoB, and the mutations are clustered in a small region. About 40 distinct point mutations and in-frame insertions and deletions in rpoB have been identified, but point mutations in two codons, those coding for...

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