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Article

Effect of rpoB mutations conferring rifampin resistance on fitness of Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 Apr 2004

Mariam Deneke H, Mengistu Yohannes, Hoffner Sven E, Andersson Dan I

Abstract excerpt

Rifampin is a major drug used in the treatment of tuberculosis infections, and increasing rifampin resistance represents a worldwide clinical problem. Resistance to rifampin is caused by mutations in the rpoB gene, encoding the beta-subunit of RNA polymerase. We examined the effect of three diffe...

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Share to Antibiotics, Antitubercular
Share to Binding, Competitive
Share to Colony Count, Microbial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Directed RNA Polymerases

Share to Drug Resistance, Bacterial

Share to Macrophages

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Source

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Identifiers

PMID: 15047531
DOI: 10.1128/AAC.48.4.1289-1294.2004
PMCID: PMC375340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15047531-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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