Article
Disequilibria in the distribution of rpoB alleles in rifampicin-resistant M. tuberculosis isolates from Germany and Sierra Leone.
Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 1997
Rinder H, Dobner P, Feldmann K, Rifai M, Bretzel G, Rüsch-Gerdes S, Löscher T
Abstract excerpt
The effectiveness of culture-independent resistance predictions by molecular techniques is dependent on the number and the frequency of accessible resistance-associated genomic mutations. We have characterized an rpoB gene region involved in rifampicin resistance in 49 Mycobacterium tuberculosis isolates resistant to rifampicin from Germany and Sierra Leone. The determined frequencies of mutations differed...
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