Article
Acquisition of rifabutin resistance by a rifampicin resistant mutant of Mycobacterium tuberculosis involves an unusual spectrum of mutations and elevated frequency.
Annals of clinical microbiology and antimicrobials - 15 Jun 2005
Anthony Richard M, Schuitema Anja R J, Bergval Indra L, Brown Tim J, Oskam Linda, Klatser Paul R
Abstract excerpt
BACKGROUND: Mutations in a small region of the rpoB gene are responsible for most rifamycin resistance in Mycobacterium tuberculosis. In this study we have sequentially generated resistant strains to first rifampicin and then rifabutin. Portions of the rpoB gene were sequenced from 131 randomly selected mutants. Second round selection resulted in a changed frequency of specific mutations. METHODS: Mycobacterium...
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