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Article

Physiological cost of rifampin resistance induced in vitro in Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 Aug 1999

Billington O J, McHugh T D, Gillespie S H

Abstract excerpt

Drug-resistant Mycobacterium tuberculosis is a major threat to public health. In clinical practice, a limited number of resistance mutations in a short sequence of the beta subunit of RNA polymerase (encoded by rpoB) have been described. Spontaneous resistance to rifampin was induced in vitro in M. tuberculosis H37Rv (ATCC 9360). Only three resistance patterns could be detected by PCR-single-strand conformation...

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Share to Antibiotics, Antitubercular
Share to DNA, Bacterial
Share to DNA-Directed RNA Polymerases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Microbial

Share to Mycobacterium tuberculosis

Share to Polymorphism, Single-Stranded Conformational

Share to Rifampin

Share to Selection, Genetic

Source

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Identifiers

PMID: 10428904
DOI: 10.1128/AAC.43.8.1866
PMCID: PMC89382

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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