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Article

Interindividual variability in nicotine metabolism: C-oxidation and glucuronidation.

Drug metabolism and pharmacokinetics - 1 Aug 2005

Nakajima Miki, Yokoi Tsuyoshi

Abstract excerpt

Nicotine has roles in the addiction to smoking, replacement therapy for smoking cessation, as a potential medication for several diseases such as Parkinson's disease, Alzheimer's disease, and ulcerative colitis. The absorbed nicotine is rapidly and extensively metabolized and eliminated to urine. A major pathway of nicotine metabolism is C-oxidation to cotinine, which is catalyzed by CYP2A6 in human livers....

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Source

Identifiers

PMID: 16141602
DOI: 10.2133/dmpk.20.227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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