Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel SNP in COMT is associated with alcohol dependence but not opiate or nicotine dependence: a case control study.

Behavioral and brain functions : BBF - 31 Dec 2011

Voisey Joanne, Swagell Christopher D, Hughes Ian P, Lawford Bruce R, Young Ross M D, Morris C Phillip

Abstract excerpt

BACKGROUND: It is well established that COMT is a strong candidate gene for substance use disorder and schizophrenia. Recently we identified two SNPs in COMT (rs4680 and rs165774) that are associated with schizophrenia in an Australian cohort. Individuals with schizophrenia were more than twice as likely to carry the GG genotype compared to the AA genotype for both the rs165774 and rs4680 SNPs. Association of...

Read the complete abstract on PubMed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol-Related Disorders
Share to Australia
Share to Case-Control Studies
Share to Catechol O-Methyltransferase
Share to Opioid-Related Disorders
Share to Polymorphism, Single Nucleotide
Share to Reference Values
Share to Tobacco Use Disorder

Source

Open in PubMed Open full text

Identifiers

PMID: 22208661
DOI: 10.1186/1744-9081-7-51
PMCID: PMC3268714

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel SNP in COMT is associated with alcohol dependence but not opiate or nicotine dependence: a case control study.PMID 22208661Read ↗

A COMT gene haplotype associated with methamphetamine abuse.Semantic proximity Read ↗

Association between COMT gene rs165599 SNP and schizophrenia: A meta-analysis of case-control studies.Semantic proximity Read ↗

HapMap tag-SNP analysis confirms a role for COMT in schizophrenia risk and reveals a novel association.Semantic proximity Read ↗

Meta-analysis of association between genetic variants in COMT and schizophrenia: an update.Semantic proximity Read ↗

Are genetic variants of COMT associated with addiction?Semantic proximity Read ↗

Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study.Semantic proximity Read ↗

Association study of candidate variants of COMT with neuroticism, anxiety and depression.Semantic proximity Read ↗

Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations.Semantic proximity Read ↗

The differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophrenia.Semantic proximity Read ↗

Genetic variants in COMT and neurocognitive impairment in families of patients with schizophrenia.Semantic proximity Read ↗

Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence.Semantic proximity Read ↗

Association study between the rs165599 catechol-O-methyltransferase genetic polymorphism and schizophrenia in a Brazilian sample.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.