Association study between the rs165599 catechol-O-methyltransferase genetic polymorphism and schizophrenia in a Brazilian sample.

doi:10.1590/s0004-282x2012001200002

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Article

Association study between the rs165599 catechol-O-methyltransferase genetic polymorphism and schizophrenia in a Brazilian sample.

Arquivos de neuro-psiquiatria - 1 Dec 2012

Cordeiro Quirino, Silva Renata Teixeira da, Vallada Homero

Abstract excerpt

Schizophrenia is a severe psychiatric disorder with frequent recurrent psychotic relapses and progressive functional impairment. It results from a poorly understood gene-environment interaction. The gene encoding catechol-O-methyltransferase (COMT) is a likely candidate for schizophrenia. Its rs165599 (A/G) polymorphism has been shown to be associated with alteration of COMT gene expression. Therefore, the...

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PMID: 23295417
DOI: 10.1590/s0004-282x2012001200002

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COMT

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