Article
Association study of candidate variants of COMT with neuroticism, anxiety and depression.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Oct 2008
Wray Naomi R, James Michael R, Dumenil Troy, Handoko Herlina Y, Lind Penelope A, Montgomery Grant W, Martin Nicholas G
Abstract excerpt
The Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) is one of the most widely tested variants for association with psychiatric disorders, but replication has been inconsistent including both sex limitation and heterogeneity of the associated allele. In this study we investigate the association between three SNPs from COMT and anxiety and depression disorders and neuroticism all...
Topics
- Anxiety
- Australia
- Catechol O-Methyltransferase
- Depression
- Family Health
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Neurotic Disorders
- Polymorphism, Single Nucleotide
- Sex Factors