Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study.

doi:10.1093/ntr/nts334

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Article

Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco - 1 Jul 2013

Mutschler Jochen, Abbruzzese Elvira, von der Goltz Christoph, Dinter Christina, Mobascher Arian, Thiele Holger, Diaz-Lacava Amalia, Dahmen Norbert, Gallinat Jürgen, Majic Tomislav, Petrovsky Nadine, Thuerauf Norbert, Kornhuber Johannes, Gründer Gerhard, Rademacher Lena, Brinkmeyer Juergen, Wienker Thomas, Wagner Michael, Winterer Georg, Kiefer Falk

Abstract excerpt

BACKGROUND: The catechol-O-methyltransferase (COMT) modulates dopaminergic neurotransmission in the prefrontal cortex as well as in the mesolimbic reward system. Since the reward system mediates addictive behavior, the COMT gene is a strong candidate gene regarding the pathophysiology of tobacco dependence and smoking behavior. Because of rather conflicting results in previous studies, the purpose of the present...

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PMID: 23288874
DOI: 10.1093/ntr/nts334

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COMT

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