Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic association between human chitinases and lung function in COPD.

Human genetics - 1 Jul 2012

Aminuddin F, Akhabir L, Stefanowicz D, Paré P D, Connett J E, Anthonisen N R, Fahy J V, Seibold M A, Burchard E G, Eng C, Gulsvik A, Bakke P, Cho M H, Litonjua A, Lomas D A, Anderson W H, Beaty T H, Crapo J D, Silverman E K, Sandford A J

Abstract excerpt

Two primary chitinases have been identified in humans--acid mammalian chitinase (AMCase) and chitotriosidase (CHIT1). Mammalian chitinases have been observed to affect the host's immune response. The aim of this study was to test for association between genetic variation in the chitinases and phenotypes related to chronic obstructive pulmonary disease (COPD). Polymorphisms in the chitinase genes were selected...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Bronchoalveolar Lavage Fluid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Chitinases

Share to Forced Expiratory Volume

Share to Pulmonary Disease, Chronic Obstructive

Share to Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 22200767
DOI: 10.1007/s00439-011-1127-1
PMCID: PMC3771523

Genes

CHIT1
FEV

Variants

rs2494303

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic association between human chitinases and lung function in COPD.PMID 22200767Read ↗

The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases.Semantic proximity Read ↗

Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit.Semantic proximity Read ↗

Chitinase 3-like 1 polymorphisms and risk of chronic obstructive pulmonary disease and asthma in a Chinese population.Semantic proximity Read ↗

Polymorphisms and Haplotypes of Acid Mammalian Chitinase Are Associated with Bronchial AsthmaSemantic proximity Read ↗

Genetic polymorphisms of chitotriosidase in Caucasian children with bronchial asthma.Semantic proximity Read ↗

Genetic association of acidic mammalian chitinase with atopic asthma and serum total IgE levels.Semantic proximity Read ↗

Association between risk of asthma and gene polymorphisms in CHI3L1 and CHIA: a systematic meta-analysis.Semantic proximity Read ↗

Role of mammalian chitinases in asthma.Semantic proximity Read ↗

Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.Semantic proximity Read ↗

Loss and Gain of Human Acidic Mammalian Chitinase Activity by Nonsynonymous SNPs.Semantic proximity Read ↗

Fungal exposure modulates the effect of polymorphisms of chitinases on emergency department visits and hospitalizations.Semantic proximity Read ↗

Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.