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Article

Loss and Gain of Human Acidic Mammalian Chitinase Activity by Nonsynonymous SNPs.

Molecular biology and evolution - 1 Dec 2016

Okawa Kazuaki, Ohno Misa, Kashimura Akinori, Kimura Masahiro, Kobayashi Yuki, Sakaguchi Masayoshi, Sugahara Yasusato, Kamaya Minori, Kino Yoshihiro, Bauer Peter O, Oyama Fumitaka

Abstract excerpt

Acidic mammalian chitinase (AMCase) is implicated in asthma, allergic inflammation, and food processing. Little is known about genetic and evolutional regulation of chitinolytic activity of AMCase. Here, we relate human AMCase polymorphisms to the mouse AMCase, and show that the highly active variants encoded by nonsynonymous single-nucleotide polymorphisms (nsSNPs) are consistent with the mouse AMCase sequence....

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Source

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Identifiers

PMID: 27702777
DOI: 10.1093/molbev/msw198
PMCID: PMC5100053

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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