Article
The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases.
Current opinion in allergy and clinical immunology - 1 Oct 2009
Ober Carole, Chupp Geoffrey L
Abstract excerpt
PURPOSE OF REVIEW: The present review provides an overview of the chitinase and chitinase-like proteins, chitotriosidase (CHIT1), YKL-40, and acid mammalian chitinase, and summarizes the genetic studies of asthma and immune-mediated diseases with polymorphisms in the genes encoding these proteins, CHIT1, CHI3L1, and CHIA, respectively. RECENT FINDINGS: Polymorphisms in the CHIT1, CHIA, and CHI3L1 genes influence...
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