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Article

Polymorphisms and Haplotypes of Acid Mammalian Chitinase Are Associated with Bronchial Asthma

22 Sept 2005

Abstract excerpt

RATIONALE: Chitinases are enzymes that cleave chitin, a polysaccharide contained in many parasites of humans. Recent studies in mouse models of bronchial asthma have shown that acid mammalian chitinase (AMCase) is involved in the pathophysiology of asthma. It acts downstream of interleukin-13; inhibition of AMCase leads to an abrogated T-helper cell 2 inflammation, less bronchial hyperreactivity, and fewer...

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PMID: 16179638
DOI: 10.1164/rccm.200506-890oc

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