Article
Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40.
The Journal of allergy and clinical immunology - 1 Jul 2015
Gomez Jose L, Crisafi Gina M, Holm Carole T, Meyers Deborah A, Hawkins Gregory A, Bleecker Eugene R, Jarjour Nizar, Cohn Lauren, Chupp Geoffrey L
Abstract excerpt
BACKGROUND: Single nucleotide polymorphisms (SNPs) in the chitinase 3-like 1 (CHI3L1) promoter, the gene encoding YKL-40, are associated with circulating YKL-40 levels and asthma prevalence. However, the effects of gene polymorphisms on asthma severity and airway expression of YKL-40 have not been examined. OBJECTIVE: We sought to determine the effect of genetic variation in CHI3L1 on asthma severity and YKL-40...
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