Article
Genetic association of acidic mammalian chitinase with atopic asthma and serum total IgE levels.
The Journal of allergy and clinical immunology - 1 Jul 2008
Chatterjee Rajshekhar, Batra Jyotsna, Das Sudipta, Sharma Surendra Kumar, Ghosh Balaram
Abstract excerpt
BACKGROUND: In view of the hygiene hypothesis and the involvement of acidic mammalian chitinase (CHIA) in the effector responses of IL-13 with asthma, CHIA (GeneID-27159) is a potential asthma candidate gene. OBJECTIVE: To investigate the association of CHIA polymorphisms with atopic asthma and serum total IgE levels. METHODS: Twenty-one single nucleotide polymorphisms were identified by sequencing DNA of 60...
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