Article
Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit.
The Journal of allergy and clinical immunology - 1 Nov 2008
Seibold Max A, Donnelly Samantha, Solon Margaret, Innes Anh, Woodruff Prescott G, Boot Rolf G, Burchard Esteban González, Fahy John V
Abstract excerpt
BACKGROUND: Chitinolytic enzymes play important roles in the pathophysiology of allergic airway responses in mouse models of asthma. Acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT1) have chitinolytic activity, but relatively little is known about their expression in human asthma. OBJECTIVE: We sought to determine the expression and activity of AMCase and CHIT1 in healthy subjects, subjects with...
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