Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.

doi:10.1074/jbc.M109.012443

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Article

Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.

The Journal of biological chemistry - 17 Jul 2009

Seibold Max A, Reese Tiffany A, Choudhry Shweta, Salam Muhammad T, Beckman Kenny, Eng Celeste, Atakilit Amha, Meade Kelley, Lenoir Michael, Watson H Geoffrey, Thyne Shannon, Kumar Rajesh, Weiss Kevin B, Grammer Leslie C, Avila Pedro, Schleimer Robert P, Fahy John V, Rodriguez-Santana Jose, Rodriguez-Cintron William, Boot Rolf G, Sheppard Dean, Gilliland Frank D, Locksley Richard M, Burchard Esteban G

Abstract excerpt

Mouse models have shown the importance of acidic mammalian chitinase activity in settings of chitin exposure and allergic inflammation. However, little is known regarding genetic regulation of AMCase enzymatic activity in human allergic diseases. Resequencing the AMCase gene exons we identified 8 non-synonymous single nucleotide polymorphisms including three novel variants (A290G, G296A, G339T) near the gene area...

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PMID: 19435888
DOI: 10.1074/jbc.M109.012443
PMCID: PMC2740590

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