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Article

Fungal exposure modulates the effect of polymorphisms of chitinases on emergency department visits and hospitalizations.

American journal of respiratory and critical care medicine - 1 Oct 2010

Wu Ann Chen, Lasky-Su Jessica, Rogers Christine A, Klanderman Barbara J, Litonjua Augusto A

Abstract excerpt

RATIONALE: Chitinases are enzymes that cleave chitin, which is present in fungal cells. Two types of human chitinases, chitotriosidase and acidic mammalian chitinase, and the chitinase-like protein, YKL-40, seem to play an important role in asthma. We hypothesized that exposure to environmental fungi may modulate the effect of chitinases in individuals with asthma. OBJECTIVES: To explore whether interactions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20538957
DOI: 10.1164/rccm.201003-0322OC
PMCID: PMC2970860

Genes

CHIT1
CHIA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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