Article
To establish a model for the prediction of initial standard and maintenance doses of warfarin for the Han Chinese population based on gene polymorphism: a multicenter study.
European journal of clinical pharmacology - 1 Jan 2022
Xia Xiaotong, Huang Nianxu, Li Boxia, Li Yan, Zou Lang, Yuan Dongdong, Huang Banghua, Bei Yufei, Liu Yuxin, Fu Jinglan, Wu Tingting, Chen Wenjun, Jiang Shaojun, Lv Meina, Zhang Jinhua
Abstract excerpt
PURPOSE: The purpose of this paper is to study the correlation between demographic and clinical factors and warfarin dose of patients in Chinese Han population taking warfarin and study gene polymorphisms impact of related gene loci (CYP2C9*3, VKORC1-1639G > A) on warfarin doses, to establish a model to predict initial standard dose and maintenance dose based on CYP2C9*3, VKORC1-1639G > A genotype. METHODS: The...
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