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Article

The influence of genetic polymorphisms and interacting drugs on initial response to warfarin in Chinese patients with heart valve replacement.

European journal of clinical pharmacology - 1 Jun 2011

Zhong Shi-Long, Liu Yuan, Yu Xi-Yong, Xu Dan, Tan Hong-Hong, Lin Qiu-Xiong, Yang Min, Lao Hai-Yan, Lin Shu-Guang

Abstract excerpt

PURPOSE: Compared with genetic factors, drug interactions were largely unexplored in warfarin pharmacogenetic studies. This study sought to systematically investigate the effects of genetic polymorphisms of VKORC1, STX4A, CYP2C9, CYP3A4, and GGCX and interacting drugs on the initial responses to warfarin in Chinese patients with heart valve replacement (HVR). METHODS: A retrospective study was conducted in 809...

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Source

Identifiers

PMID: 21318593
DOI: 10.1007/s00228-011-0995-6

Genes

VKORC1
GGCX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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