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Article

The complex intratumoral heterogeneity of colon cancer highlighted by laser microdissection.

Digestive diseases and sciences - 1 May 2012

Buob David, Fauvel Harold, Buisine Marie-Pierre, Truant Stéphanie, Mariette Christophe, Porchet Nicole, Wacrenier Agnès, Copin Marie-Christine, Leteurtre Emmanuelle

Abstract excerpt

AIMS: To evaluate the utility of laser microdissection in the comparison of phenotypes and genetic alterations between colon cancer and corresponding liver metastasis in the context of intratumoral heterogeneity. METHODS: Immunohistochemistry was performed on a series of 11 patients surgically treated for colon adenocarcinoma with liver metastases, using antibodies directed against six mucins....

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Source

Identifiers

PMID: 22198706
DOI: 10.1007/s10620-011-2023-1

Genes

CTNNB1
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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