Article
Morphological and molecular heterogeneity in colorectal neoplasms with K-RAS mutation. A report of two cases.
Pathology, research and practice - 15 Jun 2011
Bösmüller Hans, Kranewitter Wolfgang, Webersinke Gerald, Rumpold Holger, Hackl Margit, Fend Falko
Abstract excerpt
Approximately forty percent of colorectal cancers (CRC) are characterized by activating mutations of the K-RAS gene. Determination of K-RAS mutational status as a predictive marker for anti-EGFR therapy is usually based on the assumption of intratumoral homogeneity. We present two cases of CRC in which morphologically distinct tumor components were associated with different activating mutations of K-RAS in one...
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