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Article

[Laser microdissection for the analysis of molecular heterogeneity in colorectal cancer].

Pathologie (Heidelberg, Germany) - 1 Aug 2022

Maag Nathalie, Arndt Annette, Steinestel Konrad

Abstract excerpt

BACKGROUND: Oncogenic driver mutations in RAS/RAF oncogenes are frequent in colorectal cancer (CRC). The presence of different subclones within a single tumor can lead to treatment failure in anti-EGFR/epidermal growth factor receptor-directed antibody therapies. The identification of different subclones and their mutational profiles within a single tumor and the identification of morphologically distinct tumor...

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PMID: 36255446
DOI: 10.1007/s00292-022-01131-y

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