Article
Presence of genetic alterations in microdissected stroma of human colon and breast cancers.
Anticancer research - 1 Jan 2000
Wernert N, Löcherbach C, Wellmann A, Behrens P, Hügel A
Abstract excerpt
BACKGROUND: Human carcinomas not only consist of neoplastic epithelial cells but also of tumor stroma, which may play an important role in tumor-progression. Whereas the tumor surrounding stroma is generally believed to represent a reactive component induced by tumor cell derived factors, a contribution of neoplastic cells to stroma formation via epithelium-mesenchyme transition during tumor invasion has become a...
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