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Article

Genetic and Epigenetic Intra-tumour Heterogeneity in Colorectal Cancer.

World journal of surgery - 1 May 2017

Jones Huw Geraint, Jenkins Gareth, Williams Namor, Griffiths Paul, Chambers Phil, Beynon John, Harris Dean

Abstract excerpt

INTRODUCTION: Colorectal cancer (CRC) is a highly heterogeneous disease, with pathologically similar cancers having completely different responses to treatment and patient survival. Intra-tumour heterogeneity (defined as distinct morphological and phenotypic differences) has recently been demonstrated to be an important factor in the development and behaviour of cancer cells and can be used to determine response...

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Identifiers

PMID: 28097409
DOI: 10.1007/s00268-016-3860-z
PMCID: PMC5394146

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KRAS
BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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