Article

Characterization of Spatial Heterogeneity in Metastasized Colorectal Cancer by MALDI Imaging

2023-02-21

Abstract excerpt

About 50% of colorectal cancer patients develop liver metastases. Patients with metastatic colorectal cancer have 5-year survival rates below 20% despite new therapeutic regimens. Tumor heterogeneity has been linked with poor treatment response and clinical outcome, but was so far mainly studied via bulk genomic analyses. In this study we performed spatial proteomics via MALDI mass spectrometry imaging on six pati...

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Literature Corpus work: ed4c9496-9e55-50f2-bb66-c516b2dacb66
DOI: 10.20944/preprints202302.0363.v1

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