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Article

7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Mar 2012

Johnson Rebecca A, Lam Maxine, Punzo Antonio M, Li Hongda, Lin Benjamin R, Ye Keqiang, Mitchell Gordon S, Chang Qiang

Abstract excerpt

Rett syndrome (RTT), caused by mutations in the methyl-CpG binding protein 2 gene (MECP2), is a debilitating autism spectrum developmental disorder predominantly affecting females. Mecp2 mutant mice have reduced levels of brain-derived neurotrophic factor (BDNF) in the brain; conditional deletion and overexpression of BDNF in the brain accelerates and slows, respectively, disease progression in Mecp2 mutant mice....

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Source

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Identifiers

PMID: 22194327
DOI: 10.1152/japplphysiol.01361.2011
PMCID: PMC3643819

Genes

BDNF
MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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