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Article

Treatment with desipramine improves breathing and survival in a mouse model for Rett syndrome.

The European journal of neuroscience - 1 Apr 2007

Roux Jean-Christophe, Dura Emmanuelle, Moncla Anne, Mancini Josette, Villard Laurent

Abstract excerpt

Rett syndrome (RS) is a severe X-linked neurological disorder in which most patients have mutations in the methyl-CpG binding protein2 (MECP2) gene. No effective treatment exists. We previously showed that the Mecp2-deficient mice, a mouse model of RS, have highly variable respiratory rhythm and...

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Source

Identifiers

PMID: 17439480
DOI: 10.1111/j.1460-9568.2007.05466.x

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17439480-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Treatment with desipramine improves breathing and survival in a mouse model for Rett syndrome.PMID 17439480Read ↗

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Improvement of the Rett syndrome phenotype in a MeCP2 mouse model upon treatment with levodopa and a dopa-decarboxylase inhibitor.Semantic proximity Read ↗

Selective preservation of cholinergic MeCP2 rescues specific Rett-syndrome-like phenotypes in MeCP2stop mice.Semantic proximity Read ↗

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