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Article

Treatment with desipramine improves breathing and survival in a mouse model for Rett syndrome.

The European journal of neuroscience - 1 Apr 2007

Roux Jean-Christophe, Dura Emmanuelle, Moncla Anne, Mancini Josette, Villard Laurent

Abstract excerpt

Rett syndrome (RS) is a severe X-linked neurological disorder in which most patients have mutations in the methyl-CpG binding protein2 (MECP2) gene. No effective treatment exists. We previously showed that the Mecp2-deficient mice, a mouse model of RS, have highly variable respiratory rhythm and frequent apneas due to reduced norepinephrine (NE) content, and a drastic decrease of tyrosine hydroxylase...

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Source

Identifiers

PMID: 17439480
DOI: 10.1111/j.1460-9568.2007.05466.x

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Treatment with desipramine improves breathing and survival in a mouse model for Rett syndrome.PMID 17439480Read ↗

Mecp2 Deficiency Disrupts Norepinephrine and Respiratory Systems in MiceSemantic proximity Read ↗

Breathing dysfunction in Rett syndrome: understanding epigenetic regulation of the respiratory network.Semantic proximity Read ↗

β2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome.Semantic proximity Read ↗

Loss of MeCP2 Function Across Several Neuronal Populations Impairs Breathing Response to Acute HypoxiaSemantic proximity Read ↗

Separate respiratory phenotypes in methyl-CpG-binding protein 2 (Mecp2) deficient mice.Semantic proximity Read ↗

Improvement of the Rett syndrome phenotype in a MeCP2 mouse model upon treatment with levodopa and a dopa-decarboxylase inhibitor.Semantic proximity Read ↗

Selective preservation of cholinergic MeCP2 rescues specific Rett-syndrome-like phenotypes in MeCP2stop mice.Semantic proximity Read ↗

Selective preservation of MeCP2 in catecholaminergic cells is sufficient to improve the behavioral phenotype of male and female Mecp2-deficient mice.Semantic proximity Read ↗

5-HT1A Receptor Agonist Treatment Partially Ameliorates Rett Syndrome Phenotypes in mecp2-Null Mice by Rescuing Impairment of Neuron Transmission and the CREB/BDNF Signaling Pathway.Semantic proximity Read ↗

Tsix-Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function.Semantic proximity Read ↗

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